Renal Impairment Inside of a review of patients with stop stage renal impairment, mean elimination half-life was prolonged in uremic patients because of increased volume of distribution and reduced clearance. Oxycodone should be used with warning in patients with renal impairment.

Inform feminine patients of reproductive potential that prolonged usage of oxycodone and acetaminophen tablets during pregnancy may end up in neonatal opioid withdrawal syndrome, which can be life-threatening if not identified and handled [see WARNINGS, Safety measures; PREGNANCY].

Recommend patients that are taken care of with PERCOCET for more than several weeks to not abruptly discontinue the medication. Advise patients to refer to with their medical professional for your gradual discontinuation dose schedule to taper off the medication.

Alert patients to not travel or function hazardous equipment Unless of course These are tolerant for the effects of oxycodone and acetaminophen tablets and know the way they can react on the medication [see Safety measures; INFORMATION FOR PATIENTS/CAREGIVERS].

Oxycodone and acetaminophen tablets expose patients and other consumers on the risks of opioid addiction, abuse, and misuse, which can lead to overdose and Loss of life.

To shield young children from poisoning, always lock safety caps and immediately location the medication in a safe location – one that is up and absent and out in their sight and reach.

Oxycodone and acetaminophen tablets are for oral use only. Abuse of oxycodone and acetaminophen tablets poses a risk of overdose and death. The risk is amplified with concurrent abuse of oxycodone and acetaminophen tablets with alcohol and other central anxious system depressants.

Your health care provider or pharmacist gives you the percocet class of drugs manufacturer's patient information sheet (Medication Guide) when you begin your treatment with oxycodone and each time you fill your prescription.

Oxycodone causes a reduction in motility linked with a rise in sleek muscle mass tone during the antrum of the stomach and duodenum. Digestion of foods while in the compact intestine is delayed and propulsive contractions are decreased.

Usually do not abruptly discontinue oxycodone and acetaminophen tablets inside a patient bodily dependent on opioids. When discontinuing oxycodone and acetaminophen tablets in a bodily dependent patient, progressively taper the dosage.

Serotonin syndrome: Cases of serotonin syndrome, a potentially life-threatening situation, have been reported during concomitant use of opioids with serotonergic drugs.

Suggest equally patients and caregivers with regards to the risks of respiratory melancholy and sedation when PERCOCET is used with benzodiazepines or other CNS depressants (which includes alcohol and illicit drugs). Advise patients never to push or run large machinery until the effects of concomitant use of your benzodiazepine or other CNS depressant have been determined.

Educate patients and caregivers on how to recognize respiratory depression and emphasize the value of calling 911 or receiving emergency medical help instantly within the celebration of a acknowledged or suspected overdose [see WARNINGS, LIFE-THREATENING RESPIRATORY Despair].

Suggest patients and caregivers that when medicines aren't any longer needed, they should be disposed of promptly. Expired, unwanted, or unused oxycodone and acetaminophen tablets needs to be disposed of by flushing the unused medication down the bathroom if a drug take-back selection will not be available.